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Othello Syndrome Secondary to Subthalamic Deep Brain Stimulation in Parkinson’s Disease

Deep brain stimulation (DBS) is established method of Parkinson’s disease(PD) treatment. The stimulation of the limbic portion of subthalamic nucleus (STN) might devise psychotic symptoms. PD psychosis may be related also to drug intake, especially dopamine agonists(DA). Authors present 36-year old PD patient treated with STN DBS with delusions of the marital infidelity that appeared 3 months after initiation of the stimulation and confining of l-dopa and DA to zero. Those symptoms were identified as Othello-like syndrome (OLS) and were successfully treated with both quetiapine and reprogramming of the stimulation. At one-year follow-up no recurrence of the psychotic symptoms were noted. The patient required no pharmacotherapy.


Emilia Soltan Anna, Antosik-Wojcinska, Dariusz Koziorowski, Henryk Koziara and Tomasz Mandat

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