Journal of Neuropsychiatry

Abstract

Schizophrenia is a chronic mental illness effecting 1% of the population. Multiple hypotheses were proposed in the development of Schizophrenia including Neurodevelopmental, Neurodegenerative, Glial damage, Dopamine and Glutamate irregularities. S100B is a calcium binding protein found in astroglial and Schwann cells. It has important role in CNS development and recovery after injury. Scientific evidence for elevated S100B concentrations in Schizophrenic patients is consistent. This finding was mainly considered to reflect astroglial or blood brain barrier dysfunction.